NSF launches long-awaited diversity initiative

NIH Launches Alzheimer's Disease Neuroimaging Initiative 3.

O n September 8, the National Institutes of Health (NIH) announced the launch of the next major phase of the long-running Alzheimer’s Disease Neuroimaging Initiative (ADNI), which functions as a consortium of medical and research centers investigating the causes, diagnosis, and progression of AD. ADNI3 has been funded by NIH at ;$40 million over the next 5 years, an amount that will be suppleme...

A Long-Awaited Structure Is Rev-ealed

It has been known for some time that the HIV Rev protein binds and oligomerizes on a well-defined multiple stem-loop RNA structure, named the Rev Response Element (RRE), which is present in a subset of HIV mRNAs. This binding is the first step in a pathway that overcomes a host restriction, which would otherwise prevent the export of these RNAs to the cytoplasm. Four recent publications now pro...

Big plans for small molecules: NIH launches chemical genomics initiative.

The National Institutes of Health, as part of its new " Roadmap for Medical Research, " is launching a major chemical genomics initiative. Directors of almost every institute within NIH gathered in late September to announce plans for the Roadmap, a special program to speed the transition of basic research to medical advances (see box p. 1741). Little attention was given to the chemical genomic...

Sevoflurane--a long-awaited volatile anaesthetic.

In evaluating any newly introduced anaesthetic, it is worth comparing its properties with those of a theoretical “ideal” volatile agent which would have a low solubility in blood to allow for rapid equilibration between delivered concentration and the effect site in the central nervous system (CNS). This would facilitate rapid induction of anaesthesia, allow easier titration of anaesthetic dose...

NSF/DARPA/NASA Digital Libraries Initiative: A Program Manager's Perspective